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Archives of Physiology and Biochemistry, 130 (6), 678685
Notably, usable models must satisfy several criteria: cross-center training and external validation, prospective evaluation, bias and fairness audits, and interpretable presentation
Together, these findings suggest that X(PC) triggers a caspase-1-dependent lytic cascade, but that this pathway is only partially sensitive to QVD inhibition likely due to the threshold-like nature of pyroptotic signaling, and that off-target cleavage of proteins such as the substrates uncovered during profiling contributes to this complex, PANoptotic-like cell death
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