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We also recommend that the estimand concept should be applied to new trial designs to ensure transparency and facilitate interpretation of data and comparison across trials

Verdict: Limited evidence there are plausible gut-related mechanisms and some encouraging animal findings, but published human outcome data is too sparse and too poorly reported to confirm real clinical benefits [6][1113]

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Conclusion: Where GHK-Cu Fits in a Smart Hair Loss Strategy GHK-Cu is a legitimate, well-tolerated peptide with a real (if modest) evidence base for supporting hair growth through tissue repair, angiogenesis, and anti-inflammatory mechanisms