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GLP-1 has been shown to impair gallbladder motility and contractility by inhibiting cholecystokinin secretion

For example, mixing 10 ml of bacteriostatic water into a 5 mg vial produces a 0.5 mg/ml solution so a "25-unit dose" on a U-100 syringe now delivers only 0.125 mg, half the intended amount

Some studies suggest that GLP-1 receptor agonists may have direct cardiovascular protective effects beyond their benefits on glucose lowering and weight loss

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