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That single fractionation study is the proof point researchers still cite more than fifty years later as the origin of the entire copper-peptide research field: a compound identified almost by accident in a liver-aging comparison went on to become one of the most studied metallopeptides in dermal and regenerative research

In severe cases, skin and underlying tissue can suffer necrosis (tissue death), requiring antibiotics or surgery to treat

Gene-expression studies suggest it modulates more than 60 genes involved in tissue remodeling, and laboratory work indicates it can stimulate collagen synthesis in fibroblasts by up to 70%

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