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Patients with higher body mass may have larger volumes of distribution, which could theoretically prolong elimination time, though this effect is generally modest compared to other factors

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Exendin-4, liraglutide and semaglutide can directly or indirectly stimulate POMC neurons in the ARC, while indirectly inhibiting NPY/AgRP neurons via presynaptic GABAergic neurons [82-84]

Remember, while semaglutide can be a powerful tool, it is one part of a larger puzzle that includes healthy lifestyle choices and ongoing medical guidance