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That is, investigations are warranted to better understand the potential benefit of combined use of GLP-1 RAs and SGLT2 inhibitors in HF with specific focus on the sequence of treatment initiation and the suitable population, including by HF phenotype and presence of diabetes
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Moreover, ROS levels, pivotal markers of oxidative stress, surged post-GR knockout, across total, intracellular, and supernatant ROS ratios ( P = 0.0016, P = 0.0005, and P = 0.0247, respectively) (Figures 6GI), with intracellular elevations being particularly significant
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