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Situaciones que requieren evaluacin mdica inmediata: Pancreatitis aguda: Dolor abdominal severo persistente con elevacin de enzimas pancreticas Reacciones alrgicas graves: Angioedema, anafilaxia o reacciones cutneas severas Cambios en la retinopata diabtica: Requieren evaluacin oftalmolgica urgente y decisin individualizada sobre continuar o modificar el tratamiento, especialmente en pacientes con retinopata preexistente y reduccin glucmica rpida Embarazo confirmado: Los agonistas GLP-1 deben suspenderse al confirmar embarazo

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At the immune cell level, when monocytes/macrophages and dendritic cells shift from relatively silent apoptosis to necroptosis upon stimulation by pathogen-associated molecular patterns (PAMPs), it is often accompanied by the release of a large amount of cytokines and chemokines such as IL-6, TNF-, and CCL2, shaping a high inflammation, low resolution immune phenotype, weakening immune tolerance and inflammatory resolution pathways (79)

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So far, no trials have been published that compare different dual- or triple-receptor agonists with each other

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