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The STEP 1 trial (Wilding et al., New England Journal of Medicine 2021) used this exact titration in the semaglutide 2.4 mg arm and found that 86.4% of participants reached the 2.4 mg maintenance dose by week 20
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They revealed that metabolic signals originating in the gut influence neural circuits governing reward, craving, decision-making, and reinforcement
Are Tirzepatide and Semaglutide the Same
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