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The copper ion in AHK-Cu is suggested to be involved in enzyme activity related to collagen and elastin synthesis
While clinical validation of this mechanistic advantage continues to evolve, the dual-inhibition profile positions Polmacoxib as a promising therapeutic option for managing osteoarthritis
A: Multiple pathways: GH receptor upregulation, nitric oxide system modulation, VEGF-promoted angiogenesis, and direct inflammatory cytokine interaction
All participants completed the Rand 36 (Dutch version) ( TM armband for 5 days before starting treatment
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