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In addition, other studies suggested that the vasorelaxant effects of GLP-1 were mediated by activation of AMP or KATP channels independently of nitric oxide and the endothelium [73, 74]
Both are usually taken once a week through injection
[0180] Fusion protein 1 and fusion protein 2 were constructed based on the semaglutide precursor with 2-5 amino acids missing from the N-terminus shown in SEQ ID NO:1 or SEQ ID NO:2 [0181] The amino acid sequence of fusion protein 1 is shown in SEQ ID NO:4: [0182] MVSKGEELFTGV KLTLKFICTTYVQERTISFKDTYKTRAEVKFEGD ENLYFQGDDDDKEGTFTSDVSSYLEGQAA K EFIAWLVRGRG [0183]Th
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