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A similar phenomenon has been observed at the calcitonin receptor, another class B1 GPCR, where human calcitonin, with a fast off-rate, turns over G protein faster than salmon calcitonin, which has a slow off-rate, and this was related to differences in the residency time of the G protein on the receptor and to the sensitivity of the G protein to GTP 35
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A medication that patients are already motivated to take (because theyre seeing weight loss and metabolic benefits) and that simultaneously reduces alcohol cravings could change the treatment landscape dramatically
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