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Due to the presence of the BBB, the concentration of aspartate and glutamate in the brain always remains at the required level,safe for the normal function of the brain [2, 36] Regulation of the proteins transport from blood to the brain The BBB participates in the formation of the CSF, which is produced from blood plasma by filtration in the vascular plexus
Prior studies showed that 17-estradiol protects neurons from developing IR, and that ovarian hormones also contribute to regulate phosphorylation of IRS-1 [78]
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