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Defenition of CKM and relation to cardiovascular outcomes
In February 2026, full results from the REDEFINE 2 study showed CagriSema achieving 23% weight loss at 84 weeks but falling short of its primary endpoint under the treatment policy estimand (which measures efficacy across all patients regardless of whether they completed treatment, rather than only those who remained on it)
For a broader overview of the most common reactions people notice when they start treatment, see our guide to common GLP-1 side effects
Signs such as right upper abdominal pain, fever, or yellowing of the skin or eyes should prompt urgent medical assessment
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