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Your prescriber should provide a clear plan for discontinuation to avoid withdrawal symptoms

Primarily summarized into 3 main MOA: MOA: Increases Insulin release/sensitivity, decreases glucagon release MOA: Slows gastric emptying (gastric peristalsis) MOA: Appetite Suppression Patho 101: Plasma glucose is maintained by a tug-of-war between the hypoglycemic effect of insulin and the hyperglycaemic effect of glucagon

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Importantly, this relationship is relevant to humans as individuals with exceptional longevity are enriched with functional IGF-1R mutations 13 , while low IGF-1 levels predict better survival in female nonagenarians 16