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GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) commonly cause headaches during initial weeks or after dose escalation due to altered gastric emptying, hydration changes, and metabolic adjustments

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Short-acting GLP-1 receptor agonists like exendin-4 and liraglutide have also been shown to disrupt conditioned place preference for alcohol supporting their ability to selectively attenuate the rewarding effects of alcohol (Egecioglu et al