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PubMed ID: 26275694 Stier H et al

As of July 26, 2026, 21 CFR 216.23 lists six substances that can be used through this pathway: Brilliant Blue G, cantharidin for topical use only, diphenylcyclopropenone for topical use only, N-acetyl-D-glucosamine for topical use only, squaric acid dibutyl ester for topical use only, and thymol iodide for topical use only

Rotate injection sites with each dose to prevent lipodystrophy, a condition where subcutaneous fat at the injection site changes texture due to repeated injections in the same location