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You begin at 0.6 mg daily for week one, increase to 1.2 mg for week two, then 1.8 mg for week three, 2.4 mg for week four, and finally reach the maintenance dose of 3.0 mg from week five onward
Based on these data, our three-cassette construct, which allows simultaneous expression of tag-free VP0, VP3, and VP1, appears to be much more efficient than the other two strategies in terms of the final PV1 D-antigen yields achieved
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Glutathione, a tripeptide antioxidant present in hepatocytes, rapidly binds NAPQI through glutathione S-transferase enzymes, neutralizing its toxicity
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