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The study found an inverse relation between the emptying time from the gastric pouch, and plasma GLP-1 and insulin concentration with the meal, indicating that quicker transit time led to increases in insulin and GLP-1 plasma concentration and subsequent post-prandial hypoglycemia ( Exendin-(9-39) given as an intravenous infusion to adult individuals with post-prandial hypoglycemia after gastric bypass surgery led to a blunted insulin response, suggesting that GLP-1 is responsible for the exaggerated insulin secretion in dumping syndrome ( Conclusions The importance of incretin hormones on the regulation of glucose homeostasis through pancreatic and extra-pancreatic actions is well established
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doi:10.2165/00044011-199815020-00001
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