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Negrao MV , Molkentine D, Paula AG, Hover L, Nilsson M, Vokes N, Engstrom L, Calinisan A, Waters L, Briere DM, Hallin J, Blumenschein GR, Skoulidis F, Kopetz SE , Hong DS, Gibbons DL, Olson P, Christensen J, Heymach JV
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Its molecular structure: Approximately 39 amino acids Synthetic, manufactured via Solid-Phase Peptide Synthesis Fatty acid-conjugated for extended biological half-life Rationally designed for balanced activation across GLP-1, GIP, and glucagon receptors The Phase 2 clinical trial data, published in the New England Journal of Medicine in 2023, reported substantial metabolic effects that exceeded what previous-generation single and dual agonists had produced
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