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Supplementation with GSH is generally ineffective at increasing cellular glutathione levels because most human cells cannot uptake extracellular GSH due to the lack of the membrane-bound ectoenzyme -glutamyltranspeptidase (-GT) or due to an unfavorable concentration gradient across the cell membrane 10,16
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88, 89 The Morris hepatoma, which was also suppressed by insulin, 90 was stimulated by acute fasting, 91 and it was later discovered that linoleic and arachidonic acid released from adipose tissue were the main substrates promoting tumor growth
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