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Retatrutide and newer triple agonists Newer medications like retatrutide , a triple GLP-1/GIP/glucagon receptor agonist, will likely carry similar thyroid warnings based on the same rodent C-cell tumor class effect

These include acute pancreatitis, diabetic retinopathy complications in patients with pre-existing retinopathy, acute kidney injury (particularly in the setting of dehydration from gastrointestinal losses), and hypoglycemia when used in combination with insulin or insulin secretagogues

You can microdose, which is a little controversial

Pharmaceutical companies argue that they may be more hesitant to invest in high-risk R&D