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After prolonged physical exertion, glutathione neutralizes reactive oxygen species (ROS) produced during the Krebs cycle, effectively preventing the lipid peroxidation of mitochondrial membranes and allowing them to recover and maintain efficient ATP production without suffering from premature fatigue or permanent oxidative damage.

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with a mean increase of 8 points) and tirzepatide (SUMMIT), appears to be greater than what has been reported for other HFpEF trials investigating the benefits of angiotensin receptorneprilysin inhibitor (Paragon-HF), sodiumglucose cotransporter 2 inhibitors (EMPEROR-Preserved, DELIVER) and spironolactone (TOPCAT)