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The retention concentrates in ankles, wrists, and face due to IGF-1 receptor activation in renal tubules increasing sodium reabsorption
Autophagy is initiated by the autophagy-activating protein complex that includes the UNC-51-like kinase (ULK1), autophagy-related protein 13L (ATG13L), family interacting protein of 200 kDa (FIP200), and ATG101 [254]
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