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Am J Lifestyle Med 7:395404 Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, Neuschwander-Tetri BA, Lavine JE, Tonascia J, Unalp A, Van Natta M, Clark J, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR, Nash CRN (2010) Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

Advanced / Aggressive Approach (2 mL = ~5,000 mcg/mL) Reconstitute: Add 2.0 mL bacteriostatic water to one 10 mg vial final concentration: ~5,000 mcg/mL

METH stimulates the release of excess glutamate from neurons while inhibiting its uptake by astrocytes, leading to the overactivation of NMDARs (Northrop et al., 2011)

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