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No sex-based analyses were performed because the study design was not explicitly set up to examine sex differences

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Although PYY1875 demonstrated potential in preclinical studies and showed modest efficacy in clinical studies, the authors say, its tolerability issues, particularly [GI]-related AEs, limit its clinical utility as an add-on therapy to semaglutide for weight management in obesity. The authors highlight the difficulty of translating animal success to humans and suggest that future research may find that alternative dosing schedules, more tolerable formulations, or different combination regimens yield more impressive results