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Figure 1 2 Cirrhosis-related malaise, fatigue, or lethargy 2.1 Definitions and prevalence Malaise embodies a pervasive sense of discomfort, weakness, or unease, the precise origin of which proves elusive and closely intertwines with mental well-being ( 2.2 Mechanism and causes Muscle functionality and contractility can suffer impairment either at or beyond the neuromuscular junction, termed peripheral fatigue, or proximal to it, referred to as central fatigue
Both of which heighten discomfort
This powerful peptide binds the ghrelin receptor to the pituitary gland
doi: 10.1160/TH07-01-0039 15 JeonC
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