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The evidence: Early human data
This innovation enabled: Weekly dosing instead of daily injections Significantly improved weight loss outcomes Expansion from diabetes into obesity treatment The launch of blockbuster brands: Ozempic (diabetes) Wegovy (weight loss) Rybelsus (oral GLP-1) turned GLP-1 into a household name globally
Most patients achieve best results starting conservatively at 200-250mcg daily and titrating gradually over 8-12 weeks to find their optimal maintenance dose, typically landing in the 250-350mcg range based on age, body composition, baseline IGF-1, and treatment goals
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