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In overweight/obese and/or diabetic patients, GLP-1RA therapy was not associated with an increased risk of psychiatric side effects or worsening of depressive symptoms compared with placebo and was associated with improved quality of life, control of food intake and emotional eating behavior

Lithium, in particular, remains under-prescribed despite its strong efficacy in BD, limiting its overall public health impact

Clear communication about possible causes, expected timelines, and evaluation options can help maintain confidence and adherence

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