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Since breast preadipocytes are closer to mammary epithelial cells, their expression of aromatase is more effective in carcinogenic development than that expressed elsewhere, resulting in a significant increase in local estrogen [138]
Nova Sci Publishers
At the molecular level, dysregulated cytokine signaling networks are characterized by key nodes such as TL1A, IL-23A, and IL-22, which drive coordinated inflammatory responses through JAK-dependent pathways, thereby amplifying downstream effects on non-epithelial compartments 84
To demonstrate specificity of the effect, we sought to rescue the decreased mEPSC frequency by pretreating with pyroglutamate (PGA), the precursor of glutamate that is synthesized downstream of GGT, which is blocked by acivicin (Fig
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