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While weight loss generally reduces joint loading and can improve joint pain, it may also lead to some loss of muscle mass and, in some cases, reduced bone density

Grading of the results The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to assess the quality of evidence for each outcome in the meta-analysis [24]

The plan should be to get to a healthy weight then go off the medication to maintain with the option to go back on should you find yourself putting weight on again

Although you may see changes on the scale, they are typically minor and will not have a significant impact on your overall weight