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Adjustments in concomitant anti-diabetic treatment may be needed

Mounjaro was initially approved for diabetes, but tirzepatide now also has obesity-related approvals under separate branding

In addition, we did not find a significant non-linear relationship between dose (g/day) (coefficients = 8.54, p = 0.054) and changes in HOMA-IR, although there was a significant non-linear relationship between duration of the intervention (coefficients = 0.22, p = 0.015) and changes in HOMA-IR

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