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GHK-Cu is the copper(II) complex of glycyl-L-histidyl-L-lysine (Gly-His-Lys), a tripeptide first isolated from human serum albumin in 1973 whose concentration declines with age

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The three compounds intersect at cellular energy metabolism: NAD+ as a core coenzyme, MOTS-c as a mitochondrial signaling peptide, and 5-Amino-1MQ as an enzyme inhibitor affecting NAD+ availability