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The only circumstances where compounding semaglutide or tirzepatide may be permissible are: True allergy to a specific inactive ingredient in the FDA-approved version, documented with allergy testing and medical records Documented medical need for a different concentration not commercially available, with clear clinical justification Specific patient population requiring dosage form modification , such as pediatric use, with proper medical justification Healthcare providers must document medical necessity with extensive clinical evidence

Focus on proven therapies: Current FDA-approved medications and lifestyle changes remain the safest approach

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J Psychosom Res (1994) 38(8):80114