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Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion
Another compound, PF-07081532 (sometimes called PF-08653944 after its acquisition by Pfizer), is a long-acting analog from the OPKO codevelopers, designed as a once-monthly GLP-1
Kamat PK, Kalani A, Givvimani S, Sathnur PB, Tyagi SC, Tyagi N
GLP-1s: Powerful but not simple GLP-1 receptor agonists are reshaping metabolic disease treatment, but their impact extends far beyond weight loss
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