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The FDA approved tirzepatide (brand name Mounjaro) for type 2 diabetes in 2022, but physicians have broad legal authority to prescribe approved medications for unapproved uses when evidence supports efficacy
Excretion Pathways Radiolabeled studies in humans established PT-141s elimination pathways: 64.8% of administered dose recovered in urine 22.8% of dose recovered in feces Complete elimination occurring within several days No evidence of accumulation with repeated administration The predominantly renal excretion pattern and absence of accumulation support the approved dosing regimen of no more than one dose per 24 hours and maximum eight doses per month
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