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At week 12, there was a significant difference in the CIBIC + (p=0.033) in favor of Cere

AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

NRH salvage and conversion to NAD(+) requires NRH kinase activity by adenosine kinase [PMID: 32694608] Laboratory literature summary: NRH salvage and conversion to NAD(+) requires NRH kinase activity by adenosine kinase