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Data availability Under the South African Biodiversity Act, rooibos is a protected plant and as such the data for this work will only be made available at request from the corresponding author, for scientific research purposes only

Data quality and reporting Pre-register primary endpoints, report randomization/blinding/power calculations, include sex as a biological variable, and disclose attrition

In the intravital microscopy experiments, HFD-treated SAL-treated animals exhibited increased numbers of rolling and adhesive leukocytes on cerebral vessel walls

Pregnancy and breastfeeding lack strong safety data, so avoid unless your clinician advises