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An open-label introductory period of the first 36 weeks, during which all subjects were treated with tirzepatide, followed by a 52-week double-blind treatment period, during which subjects were randomly assigned to receive either tirzepatide or placebo

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The triple-receptor approach extends the metabolic research effects of single-receptor (semaglutide) and dual-receptor (tirzepatide) predecessors by adding glucagon receptor activity which contributes to additional metabolic and energy expenditure pathways

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