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MK 677, while technically a ghrelin mimetic rather than a peptide, provides oral dosing convenience that eliminates injection supplies entirely

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A 2021 Nature Microbiology study found that an Akkermansia protein called P9 triggers GLP-1 release from intestinal L-cells in mice by activating the ICAM-2 receptor, and the bacterium's metabolite propionate can also stimulate GLP-1