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92 Similarly, in a hamster model of pancreatic cancer, high substrate levels of glucose, linoleic acid and other fatty acids mobilized through streptozocin-induced diabetes significantly enhanced tumor growth, which was prevented by insulin treatment
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That growth hormone prompts the liver to produce IGF-1, which supports protein synthesis, lean mass, and body recomposition over time
Tirzepatide may also worsen diabetic retinopathy, particularly in patients who are also using insulin, so monitoring is advised
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