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Although it could be theoretically possible to enhance the reverse cholesterol effects of LXRs without targeting hepatic lipogenesis with the use of LXR-specific ligands since most of the hepatic responses are due to activation of LXR, this will be a difficult challenge as the ligand binding pocket in both isoforms has been shown to be nearly identical

It may also be prescribed to adults with a BMI between 27 and 30 if they have at least one weight-related condition

Slower titration significantly reduces both the severity and duration of these side effects