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The question of sermorelins impact on estrogen usually comes up because some of the benefits of sermorelin, like improved muscle tone, skin thickness, and fat metabolism, overlap with those of hormone replacement therapy (HRT)

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doi: 10.1111/1440-1681.12567 86 YamadaHNakashimaYOkazakiKMawatariTFukushiJOyamadaAet al