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In both patient populations with pre-existing cardiovascular disease, DPP-4 inhibitors are recommended as one possible third-line therapy besides SGLT-2 inhibitors, thiazolidinediones, or insulin, when therapeutic goals are not met with the previous dual combination
It is worth distinguishing half-life from duration of action
Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging
Hyman says it's safe
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