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Although no data from head-to-head trials comparing retatrutide to other currently approved obesity treatments exist, data from the phase 2 studies with retatrutide suggest that at higher doses, retatrutide could lead to greater WL compared to the most efficacious approved treatments for obesity and T2D such as tirzepatide 15 mg and semaglutide 2.4 mg (Fig
PlexusDx recommends baseline health screening and ongoing provider communication before initiating any dual-medication regimen
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There is also preclinical evidence that GLP-1RAs may directly modulate pain through reduction of central sensitization, suggesting the possibility of additional symptomatic improvement for IIH patients with headache (32)
