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Phase 1 work characterised eloralintide as activating the human amylin 1 receptor roughly 12 times more potently than the human calcitonin receptor, so calcitonin engagement is minimal at clinical exposures
KPV research rarely includes this kind of analytical overhead because there is no metal to account for
In addition to increased levels of EGT, gliK was demonstrated to exhibit significant sensitivity to H 2 O 2 compared to wild-type (Gallagher et al., 2012), and it is speculated that it may be due to interruption of the gliotoxin biosynthetic pathway following the incorporation of GSH, as GliK catalyzes the enzymatic step directly following GliG-mediated GSH conjugation (Figure 3) (Davis et al., 2011)
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