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2.1.2 Method validation Method validation was carried out using established retrospective metrics, such as receiver-operating characteristics (ROC) curves, enrichment factors (EF10%) (Sheridan et al., 2001), robust initial enhancement (RIE) (Sheridan et al., 2001), Boltzmann-enhanced discrimination of ROC (BEDROC) (Truchon and Bayly, 2007), and total gain (TG) (Empereur-Mot et al., 2015) scores
Maybe they simply ran out of the lower concentration
The MHRA and EMA product information for GLP-1 receptor agonists clearly document these gastrointestinal reactions, emphasising the importance of gradual dose titration to minimise their occurrence and severity
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