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These include replicative exhaustion due to telomere shortening, DNA damage, oncogene activation, mitochondrial dysfunction, metabolic stress, proteotoxic stress, and exposure to certain inflammatory mediators or mitogens [49]
mRNA levels have served as a proxy for protein levels, although the correlation between mRNA and protein abundance has generally not been shown to be very strong, e.g., due to additional transcriptional and translational regulation 25,26,27
De-ubiquitinating enzyme, USP11, promotes transforming growth factor -1 signaling through stabilization of transforming growth factor receptor II
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