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In mice pretreated with buthionine sulfoxime to inhibit GSH synthesis and induce a deficient state, oral administration of GSH resulted in statistically significant increases in GSH concentrations in kidney, heart, lung, brain, small intestine, and skin, but not in the liver
p=0.014), EDE-QS (5.9, 95% CI:2.5,9.3
The 3-D cell model was made by culturing cells (2 10 5 1.0 10 6 ) with high glucose DMEM supplemented with 30% bovine collagen solution overnight
S-acetyl glutathione offers chemical stability and limited human pharmacokinetic evidence
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