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Regression analyses suggested that natural pregnancy was associated with weight loss and improvement in IR, indicating that the path from metabolic improvement to reproductive benefit is more likely driven by individual metabolic responses rather than by drug class alone (111, 112)

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4 Conclusion In conclusion, due to its multifaceted and heterogeneous nature, a personalized approach is necessary for obesity management, especially in syndromic obesity like PWS where the underlying pathophysiology remains largely unknown