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Glutathione, a natural antioxidant found in most cells, plays a key role in maintaining cellular health

they frequently lack appropriate specificity, chemical stability, or interference resistance to cellular components [115] and they are mostly incapable of simultaneously quantifying the intricate network of interconnected redox couples (e.g., GSH/GSSG, NAD/NADH, and Trx redox states) with adequate sensitivity under physiologically relevant conditions [116]

ERK5-CHAMP treatment led to cell cycle arrest, increased apoptosis, and reduced cell viability